Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by degeneration of the fronto temporal lobes and abnormal protein inclusions. It exhibits a broad clinicopathological spectrum and has been linked to mutations in seven different genes. We will provide a picture, which connects the products of these genes, albeit diverse in nature and function, in a network. Despite the paucity of information available for some of these genes, we believe that RNA processing and post-transcriptional regulation of gene expression might constitute a common theme in the network. Recent studies have unraveled the role of mutations affecting the functions of RNA binding proteins and regulation of microRNAs. This review will combine all the recent findings on genes involved in the pathogenesis of FTD, highlighting the importance of a common network of interactions in order to study and decipher the heterogeneous clinical manifestations associated with FTD. This approach could be helpful for the research of potential therapeutic strategies.

A network in FrontoTemporal Dementia - an RNA perspective / Fontana, Francesca; Siva, Kavitha; Denti, Michela Alessandra. - In: FRONTIERS IN MOLECULAR NEUROSCIENCE. - ISSN 1662-5099. - ELETTRONICO. - 2015:8:9(2015), pp. 1-30. [doi: 10.3389/fnmol.2015.00009]

A network in FrontoTemporal Dementia - an RNA perspective

Fontana, Francesca;Siva, Kavitha;Denti, Michela Alessandra
2015

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by degeneration of the fronto temporal lobes and abnormal protein inclusions. It exhibits a broad clinicopathological spectrum and has been linked to mutations in seven different genes. We will provide a picture, which connects the products of these genes, albeit diverse in nature and function, in a network. Despite the paucity of information available for some of these genes, we believe that RNA processing and post-transcriptional regulation of gene expression might constitute a common theme in the network. Recent studies have unraveled the role of mutations affecting the functions of RNA binding proteins and regulation of microRNAs. This review will combine all the recent findings on genes involved in the pathogenesis of FTD, highlighting the importance of a common network of interactions in order to study and decipher the heterogeneous clinical manifestations associated with FTD. This approach could be helpful for the research of potential therapeutic strategies.
8:9
Fontana, Francesca; Siva, Kavitha; Denti, Michela Alessandra
A network in FrontoTemporal Dementia - an RNA perspective / Fontana, Francesca; Siva, Kavitha; Denti, Michela Alessandra. - In: FRONTIERS IN MOLECULAR NEUROSCIENCE. - ISSN 1662-5099. - ELETTRONICO. - 2015:8:9(2015), pp. 1-30. [doi: 10.3389/fnmol.2015.00009]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/115388
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