Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia

Objective: To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia. Design: Case report. Setting: Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease. Patient: Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease. Results: Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease Conclusions: These findings expand the differential of primary progressive aphasia to include prion disease.



Titolo: Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia
Autori: David Y., Johnson; Diana L., Dunkelberger; Maya, Henry; Aissatou, Haman; Michael D., Greicius; Katherine, Wong; Stephen J., Dearmond; Bruce L., Miller; Gorno Tempini, Maria Luisa; Michael D., Geschwind
Autori Unitn: 
Gorno Tempini, Maria Luisa
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Titolo del periodico: JAMA NEUROLOGY
Anno di pubblicazione: 2013
Codice identificativo Scopus: 2-s2.0-84874065472
Codice identificativo Pubmed: 23400721
Codice identificativo ISI: WOS:000316801300016
Digital Object Identifier (DOI): http://dx.doi.org/10.1001/2013.jamaneurol.139
Handle: http://hdl.handle.net/11572/101734
Appare nelle tipologie:03.1 Articolo su rivista (Journal article)

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