Objective: To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia. Design: Case report. Setting: Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease. Patient: Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease. Results: Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease Conclusions: These findings expand the differential of primary progressive aphasia to include prion disease.

Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia

Gorno Tempini, Maria Luisa;
2013

Abstract

Objective: To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia. Design: Case report. Setting: Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease. Patient: Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease. Results: Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease Conclusions: These findings expand the differential of primary progressive aphasia to include prion disease.
David Y., Johnson; Diana L., Dunkelberger; Maya, Henry; Aissatou, Haman; Michael D., Greicius; Katherine, Wong; Stephen J., Dearmond; Bruce L., Miller; Gorno Tempini, Maria Luisa; Michael D., Geschwind
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11572/101734
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