During HIV-1 replicative cycle the gp160 envelope is processed in the secretory pathway to mature into the gp41 and gp120 subunits. Misfolded proteins located within the endoplasmic reticulum (ER) are proteasomally degraded through the ER associated degradation (ERAD) pathway, a quality control system operating in this compartment. Here we exploited the ERAD pathway to induce the degradation of gp160 during viral production, thus leading to the release of gp120 depleted viral particles.
Reduction of HIV-1 infectivity through ERAD-mediated Env depletion / Casini, Antonio; Olivieri, M.; Vecchi, L.; Burrone, O. R.; Cereseto, Anna. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 89:5(2015), pp. 2966-2971. [10.1128/JVI.02634-14]
Reduction of HIV-1 infectivity through ERAD-mediated Env depletion.
Casini, Antonio;Cereseto, Anna
2015-01-01
Abstract
During HIV-1 replicative cycle the gp160 envelope is processed in the secretory pathway to mature into the gp41 and gp120 subunits. Misfolded proteins located within the endoplasmic reticulum (ER) are proteasomally degraded through the ER associated degradation (ERAD) pathway, a quality control system operating in this compartment. Here we exploited the ERAD pathway to induce the degradation of gp160 during viral production, thus leading to the release of gp120 depleted viral particles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione
