At the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role. With the stimulus from the cell membrane and with the help from the regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner. We present a generic process model for the Rho GTP-binding proteins, and compare it with a previous model that uses ordinary differential equations. We then extend the basic model to include the behaviour of the GDIs. We discuss the challenges this extension brings and directions of further research.
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Titolo: | A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis |
Autori: | Kahramanogullari, Ozan; Luca, Cardelli; Philippa, Gardner |
Autori Unitn: | |
Titolo del volume contenente il saggio: | Proceedings of the First Workshop "From Biology To Concurrency and back (FBTC 2007) |
Luogo di edizione: | Amsterdam |
Casa editrice: | Elsevier B.V. |
Anno di pubblicazione: | 2007 |
Codice identificativo Scopus: | 2-s2.0-38649117892 |
Handle: | http://hdl.handle.net/11572/99930 |
Appare nelle tipologie: | 04.1 Saggio in atti di convegno (Paper in proceedings) |