We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.

Dependence of Sub-Micron Vaterite Container Release Properties on pH and Ionic Strength of the Surrounding Solution / Parakhonskiy, Bogdan; Tessarolo, Francesco; Haase, Albrecht; Antolini, Renzo. - STAMPA. - 86:(2012), pp. 81-85. (Intervento presentato al convegno Biomedical Applications of Smart Technologies tenutosi a Levico Terme, Italy nel 10-14 June 2012.) [10.4028/www.scientific.net/AST.86.81].

Dependence of Sub-Micron Vaterite Container Release Properties on pH and Ionic Strength of the Surrounding Solution

Parakhonskiy, Bogdan;Tessarolo, Francesco;Haase, Albrecht;Antolini, Renzo
2012-01-01

Abstract

We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.
2012
Advances in science and technology
Faenza, Italy
Trans Tech Publications (Switzerland), the Techna Group series
Parakhonskiy, Bogdan; Tessarolo, Francesco; Haase, Albrecht; Antolini, Renzo
Dependence of Sub-Micron Vaterite Container Release Properties on pH and Ionic Strength of the Surrounding Solution / Parakhonskiy, Bogdan; Tessarolo, Francesco; Haase, Albrecht; Antolini, Renzo. - STAMPA. - 86:(2012), pp. 81-85. (Intervento presentato al convegno Biomedical Applications of Smart Technologies tenutosi a Levico Terme, Italy nel 10-14 June 2012.) [10.4028/www.scientific.net/AST.86.81].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/96437
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