— Stage 2 sleep spindles are considered useful biomarkers for the integrity of the central nervous system and for cognitive and memory skills. We investigated sleep spindles patterns in subjects after 12 months of their hospitalization in the intensive care unit (ICU) of the Padova Teaching Hospital due to COVID-19 between March and November 2020. Before the nap, participants (13 hospitalized in ICU – ICU; 9 hospitalized who received noninvasive ventilation – nonICU; 9 age and sex-matched healthy controls – CTRL, i.e., not infected by COVID-19) underwent a cognitive and psychological assessment. During the nap, high-density electroencephalography (EEG) recordings were acquired. Slow (i.e., [9-12] Hz) and fast (i.e., ]12-16] Hz) spindles were automatically detected. Spindle density and spindle source reconstruction in brain grey matter were extracted. The psychological assessment revealed a statistical difference comparing CTRL and nonICU in Beck Depression Inventory score and in the Physical Quality of Life index (pvalue = 0.03). The cognitive assessment revealed a trend of worsening results in executive functions in COVID-19 survivors. Slow spindle density significantly decreased comparing CTRL to COVID-19 survivors (pvalue = 0.001). There were statistically significant differences in EEG source-waveforms fast spindle amplitude onset among the three groups, mainly between CTRL and nonICU. Our results suggest that nonICU were more susceptible to the hospitalization experience than ICU participants with a slight effect on cognitive tests. This impacted the spindle generation, revealing a decreased density of slow spindles and affecting the generators of fast spindles in COVID19 survivors, especially in nonICU.
Sleep Spindles Changes in People with Previous COVID-19 Infection / Rubega, M.; Formaggio, E.; Ciringione, L.; Bertuccelli, M.; Paramento, M.; Sparacino, G.; Vianello, A.; Masiero, S; Del, Felice. - (2022). (Intervento presentato al convegno EMBC tenutosi a Glasgow nel 11th July - 15th July 2022) [10.1109/EMBC48229.2022.9871679].
Sleep Spindles Changes in People with Previous COVID-19 Infection
Ciringione L.;
2022-01-01
Abstract
— Stage 2 sleep spindles are considered useful biomarkers for the integrity of the central nervous system and for cognitive and memory skills. We investigated sleep spindles patterns in subjects after 12 months of their hospitalization in the intensive care unit (ICU) of the Padova Teaching Hospital due to COVID-19 between March and November 2020. Before the nap, participants (13 hospitalized in ICU – ICU; 9 hospitalized who received noninvasive ventilation – nonICU; 9 age and sex-matched healthy controls – CTRL, i.e., not infected by COVID-19) underwent a cognitive and psychological assessment. During the nap, high-density electroencephalography (EEG) recordings were acquired. Slow (i.e., [9-12] Hz) and fast (i.e., ]12-16] Hz) spindles were automatically detected. Spindle density and spindle source reconstruction in brain grey matter were extracted. The psychological assessment revealed a statistical difference comparing CTRL and nonICU in Beck Depression Inventory score and in the Physical Quality of Life index (pvalue = 0.03). The cognitive assessment revealed a trend of worsening results in executive functions in COVID-19 survivors. Slow spindle density significantly decreased comparing CTRL to COVID-19 survivors (pvalue = 0.001). There were statistically significant differences in EEG source-waveforms fast spindle amplitude onset among the three groups, mainly between CTRL and nonICU. Our results suggest that nonICU were more susceptible to the hospitalization experience than ICU participants with a slight effect on cognitive tests. This impacted the spindle generation, revealing a decreased density of slow spindles and affecting the generators of fast spindles in COVID19 survivors, especially in nonICU.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione