Complex problems need complex solutions, particularly when tackling the study of diet and host interactions in homeostasis and disease, such as colorectal cancer (CRC). A myriad of factors crosslinking diet, gut microbiome, and genes must be taken into account in order to achieve solid conclusions. Recently, intestinal organoids have significantly provided a better model system in this endeavor. These emerging models mimic in vivo conditions much better than traditional cultures. In this chapter, we discuss how these emerging models may bring a completely new approach to the study gut epithelium responses to diet-related metabolites in homeostasis and CRC disease, how these 3D cultures are established, and lastly, the use of state-of-the-art of mass spectrometry and data processing techniques to obtain useful insights.

Exploiting Intestinal Organoids and Foodomics Strategies for Studying the Role of Diet and Host Responses / Peréz José, A; Garcia-Aloy, Mar; Cariglia Maria Grazia, ; Binda, Elena; Pazienza, Valerio; Rubert, Josep. - ELETTRONICO. - (2020). [10.1016/B978-0-08-100596-5.22887-4]

Exploiting Intestinal Organoids and Foodomics Strategies for Studying the Role of Diet and Host Responses

Rubert Josep
2020-01-01

Abstract

Complex problems need complex solutions, particularly when tackling the study of diet and host interactions in homeostasis and disease, such as colorectal cancer (CRC). A myriad of factors crosslinking diet, gut microbiome, and genes must be taken into account in order to achieve solid conclusions. Recently, intestinal organoids have significantly provided a better model system in this endeavor. These emerging models mimic in vivo conditions much better than traditional cultures. In this chapter, we discuss how these emerging models may bring a completely new approach to the study gut epithelium responses to diet-related metabolites in homeostasis and CRC disease, how these 3D cultures are established, and lastly, the use of state-of-the-art of mass spectrometry and data processing techniques to obtain useful insights.
2020
Reference Module in Food Science
Amsterdam (The Netherlands)
Elsevier
Peréz José, A; Garcia-Aloy, Mar; Cariglia Maria Grazia, ; Binda, Elena; Pazienza, Valerio; Rubert, Josep
Exploiting Intestinal Organoids and Foodomics Strategies for Studying the Role of Diet and Host Responses / Peréz José, A; Garcia-Aloy, Mar; Cariglia Maria Grazia, ; Binda, Elena; Pazienza, Valerio; Rubert, Josep. - ELETTRONICO. - (2020). [10.1016/B978-0-08-100596-5.22887-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/269462
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