08 Tesi di dottorato (Doctoral Thesis)

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08.1 Tesi di dottorato (Doctoral Thesis) 2392

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Signal Processing Methods for Reliable Extraction of Neural Responses in Developmental EEG

Studying newborns in the first days of life prior to experiencing the world provides remarkable insights into the neurocognitive predispositions that humans are endowed with. First, it helps us to improve our current knowledge of the development of a typical brain. Secondly, it potentially opens new pathways for earlier diagnosis of several developmental neurocognitive disorders such as Autism Spectrum Disorder (ASD). While most studies investigating early cognition in the literature are pure...

"(Un-)making" data to "make" security: A discursive and visual inquiry into the production, circulation and use of data across the pan-European information infrastructure

To counter hybrid threats – for example, international terrorism, transnational organised crime and (cyber-)attacks – security and intelligence communities increasingly gather, process and exchange vast amounts of data on presumably suspect individuals. This trend has been enabled by recent developments in surveillance capacities related to Information and Communications Technologies (ICTs). As a result, cross-border data transfers have become not only an element of international trade but al...

Design, synthesis, and preliminary biological evaluation of novel small molecules modulating the HuR RNA-binding protein and other therapeutically relevant targets in immuno-oncology.

The International Agency for Research on Cancer (IARC) estimates that 25% of men and 17% of women worldwide develop cancer during their lifetime, making it the second leading cause of death in Europe and America. Many research efforts have been directed against cancer, both from pharmaceutical companies and governmental/private organizations, and several treatments are now available. Most aim to either directly kill/block the growth of cancer cells, or to the deprivation of signals needed for...

Laser Ablation Propulsion: Synthesis and Analysis of Materials and Impulse Measurements

Among the many possible applications of laser ablation one of the more recent taken is related to nanosatellites propulsion. The study of Laser Ablation Propulsion (LAP) requires research activity on different fields like high power pulsed lasers, laser ablation itself, because it is still a problem to relate the well known mechanisms to impulse generation, and finally materials that represent the fuel in LAP. This thesis presents a research activity on LAP from its very beginning, with the d...

Touching Autism Spectrum Disorder: Somatosensory Abnormalities in Shank3b and Cntnap2 Mouse Models

Autism spectrum disorders (ASDs) represent a heterogeneous group of neurodevelopmental disorders characterised by deficits in social interaction and communication, and by restricted and stereotyped behaviour. The diagnosis of autism is based on behavioural observation of the subject as research has not yet identified specific markers. Today, several studies show that disturbances in sensory processing are a crucial feature of autism. Indeed, around 90% of individuals diagnosed with autism sho...

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