Several tumors arise from deregulated signaling pathways leading to increased proliferation and impairment of differentiation. To bypass endogenous control mechanisms and to survive the environmental stress associated with increased growth, tumor cells acquire a plethora of modifications that ultimately tend to down-regulate the ability to undergo apoptosis and exacerbate prosurvival mechanisms. Autophagy is an evolutionarily conserved mechanism through which cells recycle essential molecular constituents or eliminate damaged organelles under stress conditions imposed by nutrients or growth factors deprivation. As such, autophagy acts as a prosurvival mechanism for cancer cells. However, when overactivated, autophagy could also represent a cell death mechanism acting through self-cannibalization. Therefore, understanding the various signaling pathways that regulate autophagy could be of extreme importance. Indeed, the identification of specific molecular targets amenable to pharmacological manipulation to induce cancer cell self-cannibalization could represent a promising approach to treat apoptosis-resistant tumors.
Signal-dependent control of autophagy-related gene expression / Chiacchiera, Fulvio; Simone, C. - 453(2009), pp. 305-324.
|Titolo:||Signal-dependent control of autophagy-related gene expression|
|Autori:||Chiacchiera, Fulvio; Simone, C|
|Titolo del volume contenente il saggio:||Autophagy in Disease and Clinical Applications, Part C|
|Luogo di edizione:||Burlington|
|Casa editrice:||Academic Press|
|Anno di pubblicazione:||2009|
|Citazione:||Signal-dependent control of autophagy-related gene expression / Chiacchiera, Fulvio; Simone, C. - 453(2009), pp. 305-324.|
|Appare nelle tipologie:||02.1 Saggio su volume miscellaneo o Capitolo di libro (Essay or Book Chapter)|
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