2026-09-20T06:31:07Zhttps://iris.unitn.it/oai/request

oai:iris.unitn.it:11572/4432302026-04-03T00:46:17Zcom_11572_237821com_11572_101871col_11572_237822ou_ou00279

Unbalancing Polycomb group proteins activities during liver homeostasis and tumour formation Ferracci, Elisa Ferracci, Elisa Chiacchiera, Fulvio Settore BIO/13 - Biologia Applicata Increasing evidence demonstrated that mutations altering the activity of chromatin-modifying complexes significantly contribute to liver tumour formation and progression. Inactivating mutations of members of the polycomb complexes have been found in a subset of aggressive HCCs, mainly affecting women, and in more than 20% of CCA. To clarify the role of these chromatin-associated complexes in liver homeostasis, we used a comprehensive approach taking advantage of advanced genomics approaches, histological and histochemical techniques and novel in vivo models. Our data suggest that unbalancing Polycomb activities compromises liver homeostasis, favouring tumour formation. 2025-01-23 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/11572/443230 http://dx.doi.org/10.15168/11572_443230 10.15168/11572_443230 eng lastpage:1 numberofpages:149 info:eu-repo/semantics/closedAccess Università degli studi di Trento place:TRENTO license:Tutti i diritti riservati (All rights reserved) license uri:iris.PRI01