The brain is an endocrine target site for pituitary growth hormone (GH) and an autocrine or paracrine target site for GH produced within nervous tissue. Growth hormone receptor (GHR)-mediated GH actions in the nervous system promote neural growth and differentiation, neuroprotection, neurotransmission, neuroendocrine function and behavior. Growth hormone signaling in the nervous system involves intracellular cascades and changes in gene transcription that often result in proteomic changes in the central and peripheral nervous systems. Neural GH actions mediated through changes in protein synthesis are summarized in this brief review
Proteomic Actions of Growth Hormone in the Nervous System
Baudet, Marie Laure Michele
2011-01-01
Abstract
The brain is an endocrine target site for pituitary growth hormone (GH) and an autocrine or paracrine target site for GH produced within nervous tissue. Growth hormone receptor (GHR)-mediated GH actions in the nervous system promote neural growth and differentiation, neuroprotection, neurotransmission, neuroendocrine function and behavior. Growth hormone signaling in the nervous system involves intracellular cascades and changes in gene transcription that often result in proteomic changes in the central and peripheral nervous systems. Neural GH actions mediated through changes in protein synthesis are summarized in this brief reviewI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione