The psychological and neural mechanisms of anger and its regulation.

The ability to experience, use, and eventually control anger is crucial for maintaining well-being, achieving our goals, and building healthy relationships. Despite its relevance, the neural and psychological mechanisms behind this emotion are still in their early stages. Therefore, the present work represents an effort towards the investigation of these features of anger, where the ambition is to take a step forward to bridge the gaps between the research and clinical fields. Chapter 1 will expose an introduction on anger, while Chapter 2 will expose the evidence in literature on the neural bases of anger relying on a meta-analytic approach, where the neural bases of anger perception and anger experience will be investigated. Chapter 3 relies on a multivariate data-driven approach in order to study the neural networks of anger-related individual differences, identifying a structural network associated with trait anger and a functional network associated with anger control. Chapter 4 focuses on the neural bases of other anger-related individual differences, relying on functional connectivity analysis to investigate the frontal asymmetry hypothesis, finding an association of a left pattern of connectivity with anger externalization and a right pattern of connectivity with anger internalization. Finally, the following two chapters focused on the regulation of anger, in particular considering two different strategies, reappraisal versus suppression, and the related effect of a mindfulness course on the regulation of anger. The final chapter will summarize the evidence provided in this thesis in order to integrate the different results.