AIM: To analyse (i) cellular and vascular densities in the connective tissue interface portion of the peri-implant mucosa and (ii) tissue interactions with the titanium surface during early stages of healing.MATERIALS AND METHODS: Circumferential biopsies of peri-implant soft tissues were retrieved together with custom-made abutments at 27 implants in 21 patients after 2, 4, 6, 8 and 12 weeks of healing. Following fixation, the peri-implant soft tissue was separated from the abutments, divided into four units and embedded in paraffin. Sections were produced and prepared for immunohistochemical analysis. The abutments were examined by SEM.RESULTS: T and B cells occurred in clusters with a decreasing cell density from 4 to 8 weeks of healing in the connective tissue lateral of the abutment. Macrophages were evenly distributed in the connective tissue along the abutment/tissue interface, while polymorphonuclear (PMN) cells were confined to the tissue portion lateral to the junctional epithelium. Vascular structures showed a decrease in density from 2 to 8 weeks of healing. SEM analyses of the abutments revealed an increased presence of tissue remnants attached to the surface with increasing healing time. A biofilm was consistently observed in a supra-mucosal position, apical of which a "clear zone" occurred that separated the tissue remnants and the biofilm.CONCLUSION: Onset and resolution of inflammation together with increasing tissue attachment to the implant characterize healing of peri-implant mucosa.
Early healing of peri-implant mucosa in man / Tomasi, C.; Tessarolo, F.; Caola, I.; Piccoli, F.; Wennstrom, J. L.; Nollo, G.; Berglundh, T.. - In: JOURNAL OF CLINICAL PERIODONTOLOGY. - ISSN 1600-051X. - 43:10(2016), pp. 816-824.
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|Titolo:||Early healing of peri-implant mucosa in man|
|Autori:||Tomasi, C.; Tessarolo, F.; Caola, I.; Piccoli, F.; Wennstrom, J. L.; Nollo, G.; Berglundh, T.|
|Titolo del periodico:||JOURNAL OF CLINICAL PERIODONTOLOGY|
|Anno di pubblicazione:||2016|
|Numero e parte del fascicolo:||10|
|Codice identificativo Scopus:||2-s2.0-85027926175|
|Codice identificativo ISI:||WOS:000388357000002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/jcpe.12591|
|Citazione:||Early healing of peri-implant mucosa in man / Tomasi, C.; Tessarolo, F.; Caola, I.; Piccoli, F.; Wennstrom, J. L.; Nollo, G.; Berglundh, T.. - In: JOURNAL OF CLINICAL PERIODONTOLOGY. - ISSN 1600-051X. - 43:10(2016), pp. 816-824.|
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