08 Tesi di dottorato (Doctoral Thesis)

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08.1 Tesi di dottorato (Doctoral Thesis) 2397

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Hybrid Solutions for Mechatronics. Applications to modeling and controller design.

The task of modeling and controlling the evolution of dynamical sys- tems is one of the main objectives in mechatronics engineering. When approaching the problem of controlling physical or digital systems, the dynamical models have been historically divided into continuous-time, described by differential equations, and discrete-time, described by difference equations. In the last decade, a new class of models, known as hybrid dynamical systems, has gained popularity in the control community b...

Neural Enhancement Strategies for Robust Speech Processing

In real-world scenarios, speech signals are often contaminated with environmental noises, and reverberation, which degrades speech quality and intelligibility. Lately, the development of deep learning algorithms has marked milestones in speech- based research fields e.g. speech recognition, spoken language understanding, etc. As one of the crucial topics in the speech processing research area, speech enhancement aims to restore clean speech signals from noisy signals. In the last decades, man...

Investigating TMS–evoked potentials as a biomarker in the Alzheimer’s dementia spectrum

The use of biomarkers in Alzheimer’s disease (AD) has been fundamental for early diagnosis. Currently, biomarkers in use for clinical purposes assess the presence or quantify molecular markers of the disease, i.e., ß-amyloid or Tau protein, or quantify the medial-temporal atrophy caused by the disease. Neuroimaging techniques such as structural, functional and diffusion magnetic resonance imaging and positron-emission tomography have been essential in showing how Alzheimer’s disease pathology...

Towards individualized TMS-EEG pipelines for stroke rehabilitation: the importance of individual structural and functional variability

Stroke is the main cause of adult motor disability. Nevertheless, recent meta-analyses show that the theoretical models conceived to explain the post-stroke brain reorganization are inaccurate and therefore misleading in laying the theoretical foundation for rehabilitation protocols. Mixed results are reported especially in works investigating the excitability properties of the stroke injured brain. Shedding light on the reasons that brought to such mixed results is the central topic of this ...

Molecular mechanisms of Fam3c cardioprotective activity

Despite the urgent and broad need to develop new treatments for myocardial infarction (MI) and heart failure (HF), drug treatment to revert these pathologies has not evolved significantly over the last two decades. A key aspect underlying the epidemic burden of MI is the incapacity of the cardiac muscle to undergo regeneration in adult life. Damaged cardiac tissue typically results in irreversible loss of cardiomyocytes (CMs) with relative fibrosis and scarring. Although the massive effort so...

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