The traditional route to investigating biology by perturbing living systems or by individually purifying and characterizing component parts is giving way to more complex endeavors where chemists and physicists attempt to build cells from scratch. Parallel efforts are underway that either exploits extant biological parts or prebiotically plausible molecules. Both approaches help to reveal the underlying physical–chemical forces that give rise to cellular function and highlight the important role played by polymers in regulating biological chemical systems. Although the success in RNA and lipid chemistry has led to the reconstitution of specific facets of cellular life, our understanding of dynamic, dissipative networks is currently too incomplete to allow for the construction of a self-sustained, integrated protocell. However, the presence of shared chemistry points to a promising path forward.

Progress in synthesizing protocells / Toparlak, Omer Duhan; Mansy, Sheref S.. - In: EXPERIMENTAL BIOLOGY AND MEDICINE. - ISSN 1535-3699. - 2019, 244:4(2019), pp. 304-313. [10.1177/1535370218816657]

Progress in synthesizing protocells

Toparlak, Omer Duhan;Mansy, Sheref S.
2019-01-01

Abstract

The traditional route to investigating biology by perturbing living systems or by individually purifying and characterizing component parts is giving way to more complex endeavors where chemists and physicists attempt to build cells from scratch. Parallel efforts are underway that either exploits extant biological parts or prebiotically plausible molecules. Both approaches help to reveal the underlying physical–chemical forces that give rise to cellular function and highlight the important role played by polymers in regulating biological chemical systems. Although the success in RNA and lipid chemistry has led to the reconstitution of specific facets of cellular life, our understanding of dynamic, dissipative networks is currently too incomplete to allow for the construction of a self-sustained, integrated protocell. However, the presence of shared chemistry points to a promising path forward.
2019
4
Toparlak, Omer Duhan; Mansy, Sheref S.
Progress in synthesizing protocells / Toparlak, Omer Duhan; Mansy, Sheref S.. - In: EXPERIMENTAL BIOLOGY AND MEDICINE. - ISSN 1535-3699. - 2019, 244:4(2019), pp. 304-313. [10.1177/1535370218816657]
File in questo prodotto:
File Dimensione Formato  
2018Toparlak.pdf

Solo gestori archivio

Descrizione: first online
Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.48 MB
Formato Adobe PDF
2.48 MB Adobe PDF   Visualizza/Apri
1535370218816657.pdf

accesso aperto

Tipologia: Versione editoriale (Publisher’s layout)
Licenza: Creative commons
Dimensione 2.49 MB
Formato Adobe PDF
2.49 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/231070
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 38
social impact