We present a quantitative analysis of recent data on the kinetics of ATP hydrolysis, which has presented a puzzle regarding the load dependence of the Michaelis constant. Within the framework of coarse grained two-state ratchet models, our analysis not only explains the puzzling data, but provides a modified Michaelis law, which could be useful as a guide for future experiments.
Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors / Lattanzi, G.; Maritan, A.. - In: PHYSICAL REVIEW LETTERS. - ISSN 0031-9007. - 86:6(2001), pp. 1134-1137. [10.1103/PhysRevLett.86.1134]
Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors
Lattanzi, G.;
2001-01-01
Abstract
We present a quantitative analysis of recent data on the kinetics of ATP hydrolysis, which has presented a puzzle regarding the load dependence of the Michaelis constant. Within the framework of coarse grained two-state ratchet models, our analysis not only explains the puzzling data, but provides a modified Michaelis law, which could be useful as a guide for future experiments.File in questo prodotto:
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