Neuroimaging has consistently shown engagement of the prefrontal cortex during episodic memory tasks, but the functional relevance of this metabolic/hemodynamic activation in memory processing is still to be determined. We used repetitive transcranial magnetic stimulation (rTMS) to transiently interfere with either left or right prefrontal brain activity during the encoding or retrieval of pictures showing complex scenes. We found that the right dorsolateral prefrontal cortex (DLPFC) was crucial for the retrieval of the encoded pictorial information, whereas the left DLPFC was involved in encoding operations. This ‘interference’ approach allowed us to establish whether a cortical area activated by a memory task actually contributes to behavioral performance.

Prefrontal cortex in long-term memory: an “interference” approach using magnetic stimulation.

Miniussi, Carlo;
2001-01-01

Abstract

Neuroimaging has consistently shown engagement of the prefrontal cortex during episodic memory tasks, but the functional relevance of this metabolic/hemodynamic activation in memory processing is still to be determined. We used repetitive transcranial magnetic stimulation (rTMS) to transiently interfere with either left or right prefrontal brain activity during the encoding or retrieval of pictures showing complex scenes. We found that the right dorsolateral prefrontal cortex (DLPFC) was crucial for the retrieval of the encoded pictorial information, whereas the left DLPFC was involved in encoding operations. This ‘interference’ approach allowed us to establish whether a cortical area activated by a memory task actually contributes to behavioral performance.
2001
9
S., Rossi; S. F., Cappa; C., Babiloni; P., Pasqualetti; Miniussi, Carlo; F., Carducci; F., Babiloni; P. M., Rossini
File in questo prodotto:
File Dimensione Formato  
NN_Rossi_01.pdf

Solo gestori archivio

Tipologia: Post-print referato (Refereed author’s manuscript)
Licenza: Altra licenza (Other type of license)
Dimensione 711.5 kB
Formato Adobe PDF
711.5 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11572/145610
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 230
  • ???jsp.display-item.citation.isi??? ND
social impact